RE2 Remake... What do you think it should be...

i think  most important things are gameplay, new cameras, new ways, and all of things that we are not able to do anything about them

and don't worry about other things  
some stuff like which character has which gun or not likely costume or musics and all of these kind of stuff are easy to change by modes or just swapping
actually we are exactly looking for different taste (more interest for modding   )

so if they add a menu like re3 for atleast 8 outfits we can made our favorite and replace those which we don't like 

easy peasy 

and i think if they add few difficulty with different method and style for inventory, it make the game more popular

for example: classic inventory for easy or normal and non stop like re5 for hard or professional
(or maybe just selectable)
( i love to see a manageable inventory like re4 too )

and we are not capable to add new camera without having the engine so if they just make a classic view...
all of us (i guess) had played the game already ( some people played that more than 100 time!!)

so i think the game really need to adding a new scenario and an alternative way too

and also they are simply able to add 2 mode for play

1- horror : less weapons and ammo and herbs 
2- action : more and more weapons and...

and this is veeeeerrrrrrrry easy to do

I'll throw in my 3 cents, why not.
-expand the 2 character gameplay. Make each scenario unique for both characters, not having them retread the same locations solving mostly the same puzzles. Have some rooms exclusive to Claire or Leon or have them inaccesible until the other character unlocks them,
-3D enviroments with tpp camera,
-no or very limited malee,
-RE4 "wobbly" aiming,
-and most importantly no reticule or lasersight while aiming.

They used this idea in RE2 with the Culture Room, I liked it. Wish they'll expand on it.
residentevil.wikia.com/wiki/B4F_culture_room

This would only work with first person aiming.

I assume that you are talking about tpp aiming (like RE4). The camera is in a angle and not in a straight line with enemies, so it would be frustrating just trying to aim. That is bad game design.
It works with classic RE games because the games use static camera angles.

And that is why modern RE combat/camera wouldn't fit classic games.

Good point.
By biggest fear is that they'll turn enemies into ammo piñatas.

Look, I'm not trying to bash you here, just stating the obvious. Give me a example of a game where there is such shooting mechanics and still manages to be fun, I might change my opinion.
If there isn't such game, try modding out the laser sight from Resident Evil 4. I know Ganados ain't same as zombies but you could test out your proposed aiming style since Ganados change from running to walking once they are close enough.

With the classics, they did the most of what they had and it worked. We wouldn't be having this conversation if people didn't like that style.
While aiming you see the direction you are shooting and with later games that used the mechanic, you could randomly score a headshot even with a pistol.
There is still a risk and reward thing in the classics. You can wait for a zombie to get close and score a headshot with a shotgun; wait too long and you'll get bitten.

Considering that you ask me to find you a game with those mechanics I guess that you haven't experienced them yourself. So you're more asuming that this is bad game design rather than stating it. But if your idea of fun is shooting slow moving malee monsters from across the room who am I to argue with you. Actually the only way that one could outright dissmiss this change without even considering the possibilities it creates is someone who expects this to be a regular action game which almost nobody wants. And no, I can't think of any game that plays like this- most of the time games today rip eachother off anyway, but I that even when trying to make an impactful change there still will be poeple against that because of reasons. But to counter that I'd like you to find me a recent high profile/popular game with static camaras and firearms as the main means of combat that isn't a rerelease or remaster if you think that those mechanics hold up so well, because I think they didn't went away without a reason. Nothing comes to my mind but maybe you'll be able to prove me wrong.

I acutally followed your advice and played a bit of RE4 without the lasersight (the steam version doesn't even require modding, just changing a couple of values in the cfg if anyone would want to try that out for themselves), and to the surprise of absolutely no one it playes exactly as I expeced it would- it doesn't require a lot of imagination to figure out how much impact it would have on combat and resource management during even the most basic of encounters. Here's some observations- at ~3 meters it's not all that hard to score a headshot, at ~5m body shots are not uncommon and beyond that it's more or less a lottery. I even managed to shoot a crow. And that was me playing about 10 minutes so I didn't even have a chance to really adapt to this gameplay. After some training I'm sure you can get even more effective. I won't be playing the whole game like this because it wasn't designed to be played that way, but it proves that it is possible, and that in right hands can build an experience around it. Also that risk-reward thing is basically paraprhasing what I was writing earlier when explaing the mechanics of my ideal RE game.

Significance of pistol headshots is rather debatable- they were independant of the player and weren't awarded for skill and whatnot. To the person playing it was just a regular attack. The same way you could explain random enemy damage vaulues- this zobmie clearly bit me in the heart or whatever, because the damage done was higher the that taken from the prevous one. Shotgun headshots also weren't that risky- the distance required to score one was rather generous so the only risk involved was when the camera was placed in such a way that it obstructed your view and made it difficult to judge whether it's safe to shoot or not, but that's the "good" design for you.

Beefy Busch
Yeah, I suppose that this could remedy the situation somewhat, but in actuality the autoaim in itself is bad. It basically allows you to scan for enemies as soon as you enter a room, breaking tension and immersion. As soon as the character would snap to something you knew the room wasn't safe, ruining the potential surprise moment. It also made the game much easier since you could altually miss if you were a couple degrees too much of target- so that invited even more careful resource management. You also turned much more slowly when manual aiming (and that was before quick turning) so it was more dangerous in turn. My brother, when playing the B scenario of RE2 many times missed the Tyrant with the rocket launcher either dying at that point or having no rockets for tentacle Birkin. So you could say that the autoaim is a double edged sword with atmosphere being the price for convinience.