This is stuff just off the top of my head, but they're what I'd like to see from modders in the months to come nonetheless.
Amalgamation Models Leon's redesigned RPD uniform with Hunk's tactical gear and accessories. Hunk's gear on a recolored / retextured Elza Walker racing suit for Claire. Jerry-rigged S.T.A.R.S. uniformes for Leon and Claire.
Tweaked Costumes Claire's classic outfit with the turtleneck-ish t-shirt. A less cartoon-y classic RPD outfit for Leon, more akin to the RE4 version.
Seriously, I want to play as Sherry with a gun. Apex of horror, being that small.
Play as monsters; Licker, Mr.X, etc... if at all possible within the next 4-6 years.